Estrogen and Antiestrogen Effects on Neonatal Ovine Uterine Development1
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چکیده
منابع مشابه
Estrogen and Antiestrogen Actions on Human Prostate Cancer: A Dissertation
Prostate cancer increases its incidence with age after men in their fifth decade as the ratio of estrogen to androgen rises. Epidemiological studies indicated that high levels of estrogens are associated with the high-risk ethnic groups for prostate cancer. Therefore estrogens may be involved in prostatic carcinogenesis. It is widely believed that the actions of estrogens are mediated by estrog...
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We have investigated the effects of estrogens and antiestrogens on cellular DNA-dependent DNA polymerase activity in human breast cancer, using as a model the MCF-7 human breast cancer cell line which contains estrogen receptor. 17 beta-Estradiol had little if any effect on cytosol DNA polymerase activity or growth (total DNA per flask) of MCF-7 cells. Incubation of the cells for 4 to 6 days wi...
متن کاملRelation of estrogen receptor expression to clonal growth and antiestrogen effects on human breast cancer cells.
Expression of estrogen receptor (ER) was studied in the ER-positive human breast cancer cell line MCF-7 using immunoperoxidase staining with monoclonal antibodies to ER. Using a soft agar colony assay and liquid culture, effects of growth and the antiestrogen tamoxifen were examined. Heterogeneity in expression of ER was observed between different clones in the agar cultures as well as among ce...
متن کاملDifferential Effects of Estrogen and Antiestrogen on Transforming Growth Factor Gene Expression in Endometrial Adenocarcinoma Cells1
While antiestrogens are useful agents in the treatment of breast cancer, the usefulness of these agents in the treatment of endometrial cancer remains controversial. There is some concern that the currently available antiestrogens may have partial agonist activity in uterine tissue. To better understand the mechanisms by which estrogens and antiestrogens mod ulate growth of endometrial adenocar...
متن کاملEstrogen effects on fetal and neonatal testicular development.
In recent years, evidences have accumulated that exposure to environmental components with estrogenic activity causes reproductive disorders in human populations. Studies conducted over the past 50 years have clearly shown a continual decline in semen quality accompanied by an increase in male reproductive disorders during this period in industrial countries. As healthy gametes are a prerequisi...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2003
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.103.015990